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Cycloset Drug Interactions

Cycloset Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Cycloset is combined with any of the drugs listed above.
Combining Cycloset with an antipsychotic medication could make both medications less effective (since they work in opposite ways). In general, Cycloset should not be used in combination with an antipsychotic medication.
Certain Antidepressants
Taking Cycloset with certain depression medications can cause a group of symptoms called serotonin syndrome. These symptoms include confusion, hallucination, fast heartbeat, feeling faint, fever, sweating, muscle spasm, difficulty walking, and diarrhea.
Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
Cycloset may affect the way that the body handles chloramphenicol, possibly increasing the risk of side effects of chloramphenicol. Check with your healthcare provider before taking these medications together.
CYP 3A4 Inhibitors
Cycloset is metabolized by a specific liver enzyme known as CYP 3A4. Some other medications (known as CYP 3A4 inhibitors) slow down the activity of this enzyme, causing an increase in the level of Cycloset in the blood. This could potentially lead to serious Cycloset side effects. Check with your healthcare provider before combining Cycloset with a CYP 3A4 inhibitor.
Ergot Medications
Taking Cycloset with other ergot medications can cause serotonin syndrome, increase the risk of ergot side effects, and make the ergot medications less effective for treating migraines. Talk to your healthcare provider before taking these medications together. It is not recommended to take Cycloset within six hours of other ergot medications.
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