Byetta for Weight Loss
During clinical studies, people who were taking Byetta lost 2 to 6 pounds over 30 weeks. Although the weight loss was modest, Byetta may be a good choice for overweight people with type 2 diabetes. The clinical studies also showed that people who were taking both metformin and Byetta lost more weight, likely due to the effects of metformin.
Byetta® (exenatide) is a prescription medication licensed for the treatment of type 2 diabetes. In clinical studies, Byetta was shown to cause modest weight loss. This is likely due to Byetta slowing down the digestive tract, which can decrease appetite.
In studies of Byetta for the treatment of type 2 diabetes, people taking this drug lost more weight than people who were not taking Byetta. However, the amount of weight loss was modest; people on Byetta lost about 2 to 6 pounds over 30 weeks. People who were taking both metformin (Glucophage®) and Byetta lost the most weight, most likely due to the effects of metformin (see Metformin and Weight Loss). It is not known if Byetta will cause weight loss in people who do not have type 2 diabetes.
Even though weight loss from Byetta was modest, it is important to note that many other diabetes drugs (especially a group of medications called sulfonylureas) are known to cause weight gain, which is particularly undesirable for people with type 2 diabetes -- who may already have problems with weight gain. Therefore, even if Byetta does not cause very much weight loss, it can be a good choice for overweight people with type 2 diabetes. Talk to your healthcare provider about other ways to reach a healthy weight, including changes in diet and exercise.