Lipid Effects of Avandia
The lipid effects of Avandia can be both positive and negative. Although Avandia was shown to increase HDL cholesterol ("good" cholesterol) by 11.4 to 14.2 percent in people taking the medicine during clinical studies, it also increased LDL cholesterol ("bad" cholesterol) by 14.1 to 18.6 percent.
Does Avandia Have an Effect on Lipid Levels?Avandia® (rosiglitazone maleate) is a prescription medication used to treat type 2 diabetes. It is a member of the thiazolidinedione group of diabetes medications. Although Avandia has many beneficial effects on blood sugar, it may also have effects on good cholesterol (HDL), bad cholesterol (LDL), and free fatty acids.
In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of Avandia, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take Avandia.
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.
Cholesterol Effects of Avandia: What Does the Research Show?In studies, Avandia increased LDL cholesterol ("bad" cholesterol) by 14.1 to 18.6 percent. However, it also increased HDL cholesterol ("good" cholesterol) by 11.4 to 14.2 percent. While these changes cause an increase in total cholesterol, they usually keep the ratio of total cholesterol to HDL the same. In other words, Avandia increases both good and bad cholesterol by about the same amount.