Avandia Substitutes

In September 2010, the U.
 S. Food and Drug Administration (FDA) announced that it would be severely restricting the use of Avandia, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who cannot control their diabetes on other medications (or those who are already taking the medication and doing well) will be able to take Avandia.
 
Avandia® (rosiglitazone maleate) is a prescription medication used to treat type 2 diabetes. However, if you experience bothersome side effects, or if the medication is not adequately controlling your condition, several alternatives are available.
 
Some of these substitutes for Avandia include other diabetes medications, such as:
 
  • Thiazolidinediones
  • Sulfonylureas
  • Biguanides
  • Meglitinides
  • Alpha glucosidase inhibitors
  • Dipeptidyl peptidase inhibitors
  • Ergot alkaloids
  • Combination medications.
     
Also, in many cases, lifestyle changes have been shown to be very effective in controlling type 2 diabetes, especially early type 2 diabetes. These lifestyle changes include weight loss, more physical activity, and changes in diet.
 
Other Avandia substitutes include various types of insulin and other injectable medications, such as:
 
  • Insulin
  • Incretin mimetics
  • Amylin analogues.
     
(Click Avandia Alternatives for a more in-depth look at possible substitutes for Avandia. This article offers a list of the various medications and lifestyle changes that can be used if Avandia is not working for you or if it is causing unwanted side effects.)
 
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD