Avandia and Weight Gain: An Overview
There are a number of possible side effects with
Avandia® (
rosiglitazone maleate). Weight gain does appear to be one of them. This data comes from clinical trials where Avandia was extensively studied and its side effects were documented.
One thing to keep in mind is that rapid weight gain (more than three to five pounds in a week) is a possible sign of
congestive heart failure, another known problem with Avandia.
Avandia and Weight Gain: How Common Is It?
Before medicines are approved, they must go through several clinical studies where thousands of people are given a particular medicine and are then compared to a group of people not given the medicine.
In these studies, side effects are always documented. As a result, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
People taking Avandia alone gained about four to six pounds (on average) over a year, while people not taking Avandia lost about two pounds during the year. When Avandia was combined with insulin or certain other oral
diabetes medications, the amount of weight gain increased up to about 12 pounds.
In these studies, people who were taking higher doses of Avandia (8 mg) gained more weight than people taking lower doses of Avandia (4 mg). Also, taking Avandia with
metformin (
Glucophage®) seemed to slightly decrease the amount of weight gained.
There have been reports of people rapidly gaining large amounts of weight while taking Avandia, probably due to fluid retention. Fluid retention can be dangerous (especially in people with heart problems), so be sure to tell your healthcare provider right away if you are rapidly gaining weight.
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