Avandia and Weight Gain
Based on clinical trials documenting the side effects of Avandia, weight gain did appear to be a side effect of the medication. People taking Avandia alone gained approximately four to six pounds over a year. However, if you notice any rapid weight gain over several days, it may be a possible sign of congestive heart failure. Therefore, be sure to discuss Avandia and weight gain with your healthcare provider.
Avandia and Weight Gain: An OverviewThere are a number of possible side effects with Avandia® (rosiglitazone maleate). Weight gain does appear to be one of them. This data comes from clinical trials where Avandia was extensively studied and its side effects were documented.
One thing to keep in mind is that rapid weight gain (more than three to five pounds in a week) is a possible sign of congestive heart failure, another known problem with Avandia.
In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of Avandia, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take Avandia.
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.