A healthcare provider may prescribe Avandaryl^® (rosiglitazone and glimepiride) to help lower blood sugar levels in people with type 2 diabetes. Because Avandaryl is a combination of two diabetes medications (rosiglitazone and glimepiride), it helps your body to use its natural insulin better and also causes the pancreas to produce more insulin. Prior to taking Avandaryl, be sure to tell your healthcare provider if you have kidney or liver problems, any kind of heart problems, or an adrenal insufficiency. Your dosage of Avandaryl will vary depending on several factors, such as how well your diabetes is controlled, other medical conditions you may have, and other medications you may be taking.