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Avandaryl Warnings and Precautions

Some Avandaryl warnings and precautions include an increased risk of death due to heart or blood vessel problems, the potential dangers of fluid retention, and the possibility of macular edema. Prior to taking Avandaryl, you should talk to your healthcare provider if you have any kidney problems, heart problems, or an adrenal insufficiency. You should not take Avandaryl if you are allergic to any ingredient used to make Avandaryl or if you have diabetic ketoacidosis.

In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of Avandaryl, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take Avandaryl.
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.

Avandaryl: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Avandaryl® (rosiglitazone and glimepiride) if you have:
  • Kidney problems, including kidney failure or renal failure
  • Liver problems, including liver failure or cirrhosis
  • Heart problems of any kind, especially congestive heart failure (CHF)
  • Adrenal insufficiency or adrenal fatigue
  • Pituitary gland problems
  • Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) 
  • An upcoming surgery
  • Any allergies, including allergies to sulfa drugs, foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Having problems getting pregnant
  • Breastfeeding
  • Pre-menopausal without regular menstrual periods.
Also, tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
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Avandaryl Medication

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