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Avandaryl Warnings and Precautions
Some Avandaryl warnings and precautions include an increased risk of death due to heart or blood vessel problems, the potential dangers of fluid retention, and the possibility of macular edema. Prior to taking Avandaryl, you should talk to your healthcare provider if you have any kidney problems, heart problems, or an adrenal insufficiency. You should not take Avandaryl if you are allergic to any ingredient used to make Avandaryl or if you have diabetic ketoacidosis.
In September 2010, the U.S. Food and Drug Administration (FDA) announced that it would be severely restricting the use of rosiglitazone, one of the active ingredients in Avandaryl, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who cannot control their diabetes on other medications (or those who are already taking the medication and doing well) will be able to take Avandaryl.
You should talk with your healthcare provider prior to taking Avandaryl® (rosiglitazone and glimepiride) if you have:
- Kidney problems, including kidney failure or renal failure
- Liver problems, including liver failure or cirrhosis
- Heart problems of any kind, especially congestive heart failure (CHF)
- Adrenal insufficiency or adrenal fatigue
- Pituitary gland problems
- Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
- An upcoming surgery
- Any allergies, including allergies to sulfa drugs, foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant
- Having problems getting pregnant
- Breastfeeding
- Pre-menopausal without regular menstrual periods.
Also, tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD