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Avandaryl

How Does Avandaryl Work?

The two medications in Avandaryl work differently and have different effects in the body:
 
  • Rosiglitazone is part of a group of medications called thiazolidinediones (or sometimes called glitazones). The drug helps to improve insulin sensitivity, meaning that it helps your body to use its natural insulin better. This helps to lower blood sugar and keep it under better control.
     
  • Glimepiride is part of a class of diabetes medications known as sulfonylureas. As a sulfonylurea, glimepiride helps the pancreas to produce more insulin. It may also help the cells of the body respond to insulin better. Because of these effects, blood sugar levels decrease.
     
Avandaryl is not used for the treatment of type 1 diabetes.
 

Clinical Effects

Several studies have examined the effects of Avandaryl for the treatment of type 2 diabetes. The results are described in the following sections.
 
Hemoglobin A1c
Hemoglobin A1c (HbA1c) is a test used to measure long-term blood sugar control. For people without diabetes, HbA1c results are usually less than 6 percent, while people with diabetes usually have higher results. In one study, people taking Avandaryl lowered their HbA1c by up to 2.5 percent, on average, while people taking just rosiglitazone or just glimepiride lowered their HbA1c by only 1.7 to 1.8 percent, on average.
 
Studies have shown that the higher the HbA1c, the greater the chance for developing long-term problems related to diabetes. This includes problems such as heart disease, diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. By getting blood sugar levels under control with Avandaryl, it may be possible to decrease the chances for developing these diabetes complications.
Type 2 Diabetes: Fact or Fiction

Avandaryl Medication

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