Avandaryl Drug Interactions

Avandaryl drug interactions with other medications, such as certain decongestants, some seizure medications, and oral contraceptives, can cause the body to metabolize the medications differently than intended and may lead to problems. Some of these drug interactions with Avandaryl can increase or decrease the level of Avandaryl in your blood or can make Avandaryl less effective. As a result, some of these interactions can increase your risk of side effects or increase your chance of high blood sugar. 

In September 2010, the U.S. Food and Drug Administration (FDA) announced that it would be severely restricting the use of rosiglitazone, one of the active ingredients in Avandaryl, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who cannot control their diabetes on other medications (or those who are already taking the medication and doing well) will be able to take Avandaryl.

 

An Overview of Avandaryl Interactions

Avandaryl® (
 rosiglitazone and glimepiride) can potentially interact with several medicines. Some of the medicines that may lead to Avandaryl interactions include:
 

 

 

  • Corticosteroids, such as:

 

    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Ovapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)

 

  • Diuretics, such as:

 

 

 

 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
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