The Avandaryl dosage your healthcare provider prescribes will vary depending on several factors, such as how well your diabetes is controlled, other medical conditions you may have, and other medications you may be taking. Generally, the recommended starting Avandaryl dose is 4 mg/1 mg once daily with the first meal of the day. If necessary, your healthcare provider may slowly increase your Avandaryl dose up to a maximum dosage of Avandaryl 8 mg/4 mg once a day.
In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of Avandaryl, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take Avandaryl.
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.
Avandaryl Dosing: An IntroductionAvandaryl® (rosiglitazone and glimepiride) is a combination of two different diabetes drugs: rosiglitazone maleate (Avandia®) and glimepiride (Amaryl®). The dose of Avandaryl your healthcare provider prescribes will vary depending on a number of factors, including:
- How well your diabetes is controlled
- Other medical conditions you may have
- Other medications you may currently be taking.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.