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Avandaryl and Weight Gain

There are several side effects of Avandaryl, and weight gain does appear to be one of them. During a 28-week clinical trial, people taking Avandaryl gained about four to seven pounds on average, which was more than the amount of weight gained by people taking just rosiglitazone or just glimepiride. It is important to note that rapid weight gain of more than three to five pounds in a week is a possible sign of congestive heart failure.

Avandaryl and Weight Gain: An Overview

There are a number of possible side effects with Avandaryl® (rosiglitazone and glimepiride). Weight gain does appear to be one of them. This data comes from clinical trials where Avandaryl was extensively studied and its side effects were documented.
One thing to keep in mind is that rapid weight gain (more than three to five pounds in a week) is a possible sign of congestive heart failure, another known problem with Avandaryl.
In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of Avandaryl, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take Avandaryl.
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.
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Avandaryl Medication

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