Avandaryl and Weight Gain
There are several side effects of Avandaryl, and weight gain does appear to be one of them. During a 28-week clinical trial, people taking Avandaryl gained about four to seven pounds on average, which was more than the amount of weight gained by people taking just rosiglitazone or just glimepiride. It is important to note that rapid weight gain of more than three to five pounds in a week is a possible sign of congestive heart failure.
There are a number of possible side effects with Avandaryl® (rosiglitazone and glimepiride). Weight gain does appear to be one of them. This data comes from clinical trials where Avandaryl was extensively studied and its side effects were documented.
One thing to keep in mind is that rapid weight gain (more than three to five pounds in a week) is a possible sign of congestive heart failure, another known problem with Avandaryl.
In September 2010, the U.S. Food and Drug Administration (FDA) announced that it would be severely restricting the use of rosiglitazone, one of the active ingredients in Avandaryl, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who cannot control their diabetes on other medications (or those who are already taking the medication and doing well) will be able to take Avandaryl.
Before medicines are approved, they must go through several clinical studies where thousands of people are given a particular medicine and are then compared to a group of people not given the medicine. In these studies, the side effects are always documented. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
Over 28 weeks, people taking Avandaryl (rosiglitazone and glimepiride combined) gained about four to seven pounds on average, which was more than the amount of weight gained by people taking just rosiglitazone or just glimepiride. In these studies, people who were taking higher doses of Avandaryl gained more weight than people taking lower doses.
There have been reports of people rapidly gaining large amounts of weight while taking Avandaryl, probably due to fluid retention. Fluid retention can be dangerous (especially to people with heart problems), so be sure to tell your healthcare provider right away if you are rapidly gaining weight.