Avandaryl and Weight Gain: An Overview
There are a number of possible side effects with
Avandaryl® (
rosiglitazone and glimepiride). Weight gain does appear to be one of them. This data comes from clinical trials where Avandaryl was extensively studied and its side effects were documented.
One thing to keep in mind is that rapid weight gain (more than three to five pounds in a week) is a possible sign of
congestive heart failure, another known problem with Avandaryl.
Avandaryl and Weight Gain: How Common Is It?
Before medicines are approved, they must go through several clinical studies where thousands of people are given a particular medicine and are then compared to a group of people not given the medicine.
In these studies, the side effects are always documented. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
Over 28 weeks, people taking Avandaryl (
rosiglitazone and
glimepiride combined) gained about four to seven pounds on average, which was more than the amount of weight gained by people taking just rosiglitazone or just glimepiride. In these studies, people who were taking higher doses of Avandaryl gained more weight than people taking lower doses.
There have been reports of people rapidly gaining large amounts of weight while taking Avandaryl, probably due to fluid retention. Fluid retention can be dangerous (especially to people with heart problems), so be sure to tell your healthcare provider right away if you are rapidly gaining weight.
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