Avandaryl and Weight Gain
Avandaryl and Weight Gain: How Common Is It?Before medicines are approved, they must go through several clinical studies where thousands of people are given a particular medicine and are then compared to a group of people not given the medicine. In these studies, the side effects are always documented. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
Over 28 weeks, people taking Avandaryl (rosiglitazone and glimepiride combined) gained about four to seven pounds on average, which was more than the amount of weight gained by people taking just rosiglitazone or just glimepiride. In these studies, people who were taking higher doses of Avandaryl gained more weight than people taking lower doses.
There have been reports of people rapidly gaining large amounts of weight while taking Avandaryl, probably due to fluid retention. Fluid retention can be dangerous (especially to people with heart problems), so be sure to tell your healthcare provider right away if you are rapidly gaining weight.
Rapid Weight Gain With AvandarylOne very important point to keep in mind is that Avandaryl may worsen congestive heart failure or, in some cases, even cause heart failure. One of the main symptoms of heart failure is unexplained weight gain. In fact, people with symptoms of congestive heart failure can often have rapid weight gain (three to five pounds) over several days. This weight gain is often combined with other symptoms, such as a cough and/or swelling in the ankles, feet, or legs. Make sure to contact your healthcare provider if you notice unexplained weight gain or swelling (see Symptoms of Congestive Heart Failure for more information on heart failure symptoms).