Sulfonylureas are medications that force the pancreas to make more insulin. Because of this, they are very effective in controlling blood sugar, but are also more likely to cause dangerously low blood sugar (hypoglycemia). These medications include:
- Chlorpropamide (Diabinese®)
- Glimepiride (Amaryl®)
- Glipizide (Glucotrol®)
- Glyburide (DiaBeta®, Micronase®, Glynase®)
- Tolazamide (Tolinase®)
- Tolbutamide (Orinase®).
There are a variety of combination medications available besides Avandaryl, including:
- Alogliptin and metformin (Kazano®)
- Alogliptin and pioglitazone (Oseni®)
- Glipizide and metformin (Metaglip®)
- Glyburide and metformin (Glucovance®)
- Linagliptin and metformin (Jentadueto®)
- Pioglitazone and glimepiride (Duetact®)
- Pioglitazone and metformin (Actoplus Met®, Actoplus Met XR)
- Repaglinide and metformin (PrandiMet®)
- Rosiglitazone and metformin (Avandamet®)
- Sitagliptin and metformin (Janumet®)
- Sitagliptin and metformin XR (Janumet® XR)
- Saxagliptin and metformin (Kombiglyze™ XR)
- Sitagliptin and simvastatin (Juvisync®), which is no longer available.
Metformin (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, Riomet®) is the only biguanide medication currently available. The medication works by helping the body use its natural insulin better. It also decreases sugar (glucose) production by the liver, and decreases sugar absorption from the diet.