Avandamet Warnings and Precautions
There are many situations in which Avandamet should not be taken, as well as a number of Avandamet warnings and precautions you should be aware of before starting this drug. Since people with certain existing medical conditions should not take Avandamet, be sure to discuss your medical history with your healthcare provider prior to beginning treatment.
In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of Avandamet, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take Avandamet.
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.
Prior to taking Avandamet® (rosiglitazone and metformin), you should tell your healthcare provider if you have:
- Heart problems of any kind, especially congestive heart failure (CHF)
- Had a heart attack or stroke
- Liver problems, including liver failure or cirrhosis
- Low vitamin B12 levels (pernicious anemia)
- Kidney problems, including kidney failure (renal failure)
- An upcoming surgery or procedure (including x-rays and other radiology procedures)
- Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you:
- Are pregnant or thinking of becoming pregnant (see Avandamet and Pregnancy)
- Are breastfeeding
- Are having problems getting pregnant
- Are premenopausal without regular menstrual periods
- Drink alcohol.
Also, tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.