Avandamet Side Effects
Constipation, joint pain, and fatigue are possible side effects that may occur with Avandamet. Side effects that are most commonly reported include headache, nausea or vomiting, diarrhea, and upper respiratory tract infections. Although the side effects of Avandamet are generally minor and may not require medical attention, you should alert your healthcare provider immediately if you develop problems such as an allergic reaction, rapid weight increase, or chest pain.
In September 2010, the U.S. Food and Drug Administration (FDA) announced that it would be severely restricting the use of rosiglitazone, one of the active ingredients in Avandamet, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who cannot control their diabetes on other medications (or those who are already taking the medication and doing well) will be able to take Avandamet.
As with any medicine, there are possible side effects with Avandamet® (rosiglitazone and metformin). However, not everyone who takes Avandamet will experience side effects. In fact, most people tolerate Avandamet well. When side effects do occur, in most cases they are minor and either require no treatment or can be easily treated by you or your healthcare provider.
(The side effects discussed below are not a complete list of side effects reported with Avandamet. Your healthcare provider can discuss a more complete list of possible side effects with you.)