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Avandamet Side Effects

Constipation, joint pain, and fatigue are possible side effects that may occur with Avandamet. Side effects that are most commonly reported include headache, nausea or vomiting, diarrhea, and upper respiratory tract infections. Although the side effects of Avandamet are generally minor and may not require medical attention, you should alert your healthcare provider immediately if you develop problems such as an allergic reaction, rapid weight increase, or chest pain.

In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of Avandamet, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take Avandamet.
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.

Avandamet Side Effects: An Introduction

As with any medicine, there are possible side effects with Avandamet® (rosiglitazone and metformin). However, not everyone who takes Avandamet will experience side effects. In fact, most people tolerate Avandamet well. When side effects do occur, in most cases they are minor and either require no treatment or can be easily treated by you or your healthcare provider.
(The side effects discussed below are not a complete list of side effects reported with Avandamet. Your healthcare provider can discuss a more complete list of possible side effects with you.)
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