Avandamet is manufactured by GlaxoSmithKline.
Avandamet is a combination of two diabetes medicines (rosiglitazone and metformin). These two medications work differently and have different effects in the body:
- Rosiglitazone is part of a class of diabetes medication called thiazolidinediones (or sometimes called "glitazones"). Rosiglitazone helps to improve insulin sensitivity. This means that rosiglitazone helps your body respond to insulin better, which helps to lower blood sugar.
- Metformin works in several ways. For example, it decreases the amount of sugar (glucose) made by the liver. It can also decrease the amount of sugar absorbed into the body (from the diet) and can make insulin receptors more sensitive, helping the body respond to its own insulin better. All of these effects cause a decrease in blood sugar levels.
Because Avandamet does not increase the amount of insulin the body produces, it is less likely to cause dangerously low blood sugar (hypoglycemia), as many other diabetes drugs can do (see Avandamet Alternatives and Avandamet and Blood Sugar for more information). It is not intended to be used for the treatment of type 1 diabetes (see Avandamet and Type 1 Diabetes for more information).
There have been several studies looking at the effects of Avandamet for type 2 diabetes: