Avandamet Drug Interactions
Avandamet drug interactions may potentially occur if the diabetes drug is taken with medicines such as: oral contraceptives, gemfibrozil, calcium channel blockers, or diuretics. Avandamet interactions may increase the drug levels in your blood, reduce the effectiveness of the medications, or increase the risk of side effects. These problems may require your healthcare provider to monitor you more closely or adjust your dosage as needed.
In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of Avandamet, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take Avandamet.
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.
Avandamet® (rosiglitazone and metformin) can potentially interact with several medicines. Some of the medicines that can lead to Avandamet drug interactions include:
- Certain decongestants, such as phenylephrine (Sudafed PE®) or pseudoephedrine (Sudafed®)
- Certain seizure medications, including:
- Diuretics, such as:
- Gemfibrozil (Lopid®)
- Niacin (nicotinic acid, Niaspan®, Niacor®, Nicolar®)
- Oral contraceptives (birth control pills)
- Phenothiazine medications, including: