Avandamet Drug Interactions

Avandamet drug interactions may potentially occur if the diabetes drug is taken with medicines such as: oral contraceptives, gemfibrozil, calcium channel blockers, or diuretics. Avandamet interactions may increase the drug levels in your blood, reduce the effectiveness of the medications, or increase the risk of side effects. These problems may require your healthcare provider to monitor you more closely or adjust your dosage as needed.

In September 2010, the U.S. Food and Drug Administration (FDA) announced that it would be severely restricting the use of rosiglitazone, one of the active ingredients in Avandamet, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who cannot control their diabetes on other medications (or those who are already taking the medication and doing well) will be able to take Avandamet.
 

Avandamet Interactions: An Overview

Avandamet® (
 rosiglitazone and metformin) can potentially interact with several medicines. Some of the medicines that can lead to Avandamet drug interactions include:
 
 
 
 
 
 
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Ovapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 
  • Diuretics, such as:
 
 
 
 
Avandamet Drug Interactions Article Continues on Next Page >
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
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