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Avandamet Drug Interactions

Diuretics
Taking Avandamet with diuretics can make Avandamet less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Avandamet dose, especially when starting or stopping a diuretic.
 
Taking Avandamet with furosemide (a diuretic) can affect the levels of both furosemide and Avandamet in your blood. This may increase your risk of Avandamet side effects and may make furosemide less effective. Your healthcare provider may need to adjust your dose of these medications.
 
Estrogens
Taking Avandamet with estrogens can make Avandamet less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Avandamet dose, especially when starting or stopping an estrogen.
 
Gemfibrozil (Lopid)
Taking Avandamet with gemfibrozil can increase the level of Avandamet in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of Avandamet.
 
Insulin
In studies, people taking rosiglitazone (one of the components of Avandamet) and insulin had an increased risk of congestive heart failure (CHF) or heart attacks. In general, it is not recommended to combine Avandamet with insulin.
 
Isoniazid
Taking Avandamet with isoniazid can make Avandamet less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Avandamet dose, especially when starting or stopping isoniazid.
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