For most people who are first beginning type 2 diabetes treatment with Avandamet, dosing usually starts at 2 mg/500 mg once or twice a day. If you are switching from your existing rosiglitazone prescription or metformin prescription to the combination medicine, your new Avandamet dosage will depend on how much rosiglitazone or metformin you were previously taking. The maximum daily dose of Avandamet is 8 mg/2000 mg.
In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of Avandamet, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take Avandamet.
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.
Avandamet® (rosiglitazone and metformin) is a combination of two different diabetes drugs: rosiglitazone maleate (Avandia®) and metformin hydrochloride (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Riomet®). The dose of Avandamet that your healthcare provider prescribes will vary depending on a number of factors, including:
- How well your diabetes is controlled
- Other medical conditions you may have
- Other medications you may currently be taking.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.