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Avandamet and Pregnancy

It is generally not recommended to use Avandamet during pregnancy. This is because during animal studies on Avandamet and pregnancy, the diabetes medication was shown to decrease the growth of babies and cause miscarriages during mid-to-late pregnancy. Since animals do not always respond to medicines that same way that humans do, Avandamet can still be given to a pregnant woman if her healthcare provider believes that the benefits outweigh any possible risks to the unborn child.

Avandamet During Pregnancy -- Is It Safe?

For people who are pregnant, Avandamet® (rosiglitazone and metformin) may not be safe. This is based on animal studies that looked at the effects of Avandamet during pregnancy. Avandamet is a combination of two different diabetes medications: rosiglitazone maleate (Avandia®) and metformin hydrochloride (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Riomet®).
In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of Avandamet, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take Avandamet.
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.
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