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Apidra Warnings and Precautions

Some of the Apidra warnings and precautions to be aware of include the risk of low blood sugar levels, the potential for allergic reactions, and the safety of taking the medication while pregnant or breastfeeding. People who have liver or kidney disease may not be able to safely use Apidra. Warnings and precautions also apply to people who have certain allergies.

Apidra: What Should I Tell My Healthcare Provider?

Talk with your healthcare provider prior to taking Apidra® (insulin glulisine) if you have:
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Apidra Warnings and Precautions

Precautions and warnings to be aware of prior to taking Apidra include the following:
  • If you use Apidra in an insulin pump, do not dilute it or mix it with other insulins.
  • If you inject Apidra, it may be mixed with NPH insulin, but not with any other types of insulin.
  • Apidra is used to control blood sugar levels after a meal. Once you take a dose, you must begin eating the meal within 15 minutes.
  • Low blood sugar (hypoglycemia) is the most common (and usually most serious) side effect of insulin medications, including Apidra. Make sure you and those around you know how to identify the warning signs for low blood sugar and how to respond. You must test your blood sugar levels regularly while taking Apidra or any other insulin. Low blood sugar levels can be a life-threatening problem.
  • Liver and kidney problems may affect your Apidra dosage. Also, changes in diet or exercise, illness, or stress may affect your blood sugar levels in such a way that your dosage needs to be adjusted.
  • Make sure your healthcare provider shows you exactly how to inject Apidra, how to store the drug, and how to dispose of your used needles.
  • This diabetes medication can potentially interact with several other medications (see Apidra Drug Interactions).
  • Apidra is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Apidra and Pregnancy).
  • It is not known if Apidra passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Apidra and Breastfeeding).
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