Amaryl Drug Interactions

Amaryl drug interactions with other medications, such as certain decongestants, some seizure medications, and diuretics, can change the way the medications are absorbed into the blood. Some of these drug interactions with Amaryl can increase your risk of low blood sugar or increase the level of Amaryl in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to monitor you more closely and/or adjust your dose of these medications.

 

An Overview of Amaryl Drug Interactions

 Amaryl® (glimepiride) can potentially interact with many drugs. Some of the drugs that may lead to Amaryl interactions include:
 
o Betamethasone (Celestone®)
o Cortisone
o Dexamethasone (Decadron®)
o Fludrocortisone (Florinef®)
o Hydrocortisone (Cortef®)
o Methylprednisolone (Depo-Medrol®, Medrol®)
o Prednisolone (Ovapred®, Pediapred®)
o Triamcinolone (Kenalog®, Aristospan®)
  • Diuretics, such as:
o Acetazolamide (Diamox®)
o Chlorthalodone
  • Estrogens
     
  • Isoniazid
     
  • Monoamine oxidase inhibitors (MAOIs), including
  • Niacin (nicotinic acid, Niaspan®, Niacor®, Nicolar®)
     
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
o Ibuprofen (Motrin®, Advil®)
o Diclofenac (Cataflam®, Voltaren®)
o Ketoprofen (Orudis®)
o Promethazine (Phenergan®)
  • Rifampin (Rifadin®) or rifapentine (Priftin®)
     
  • Salicylates, such as aspirin, choline magnesium trisalicylate (Trilisate®), diflunisal (Dolobid®), and salsalate (Salflex®, Disalcid®, Amigesic®)
     
  • Sulfonamides ("sulfa drugs"), including sulfadiazine, sulfadoxine (Fansidar®), sulfamethoxazole (Bactrim®, Septra®), and sulfisoxazole (Gantrisin®)
     
  • Thyroid medications, such as levothyroxine (Levothroid®, Levoxyl®, Synthroid®, Unithroid®), liothyonine (Cytomel®), thyroid (Armour Thyroid®), and Thyrolar®
     
  • Warfarin (Coumadin®, Jantoven®).
     
(Amaryl Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;