Actos Drug Interactions
When gemfibrozil, oral contraceptives, or certain seizure medications are taken together with Actos, drug interactions can occur. These interactions may significantly increase or decrease the levels of Actos in your blood and lead to side effects. Other medications that may cause Actos drug interactions include atazanavir, ketoconazole, ritonavir, and nifedipine.
Actos Drug Interactions: An Overview
Actos® (pioglitazone hydrochloride) can potentially interact with several medicines. Some of the medicines that can lead to Actos drug interactions include:
- Atazanavir (Reyataz®)
- Atorvastatin (Lipitor®) or combination medications that contain atorvastatin (Caduet®, Liptruzet™)
- Certain seizure medications, including:
- Gemfibrozil (Lopid®)
- Ketoconazole (Nizoral®)
- Midazolam (Versed®)
- Nifedipine (Adalat®, Procardia®)
- Oral contraceptives
- Rifampin (Rifadin®) or rifapentine (Priftin®)
- Ritonavir (Norvir®).
Actos Interactions Explained
Taking Actos with atanazavir can increase the level of Actos in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of Actos.
In studies, taking Actos with atorvastatin decreased the level of both Actos and atorvastatin in the blood, perhaps making them both less effective. Your healthcare provider may need to adjust your dose of these medications.