Sodium-Glucose Co-Transporter 2 Inhibitors
SGLT2 inhibitors work by causing glucose to be lost from the bloodstream into the urine. There are three approved medications in this class: Invokana® (canagliflozin), Farxiga™ (dapagliflozin), and Jardiance® (empagliflozin). These medications tend to lower blood pressure and cause a small amount of weight loss, which can often be desirable effects in people with type 2 diabetes.
Bile Acid SequestrantsOften overlooked as a diabetes drug, Welchol® (colesevelam) is a bile acid sequestrant that was initially approved for treating high cholesterol but was later approved for treating type 2 diabetes. It helps to lower both blood sugar and cholesterol levels, which can be very useful in many people with diabetes. The downside is that the usual dosage involves taking six tablets a day. It can also bind with (and therefore interact with) some other drugs.
There are a variety of combination medications available, including:
- Alogliptin and metformin (Kazano®)
- Alogliptin and pioglitazone (Oseni®)
- Glipizide and metformin (Metaglip®)
- Glyburide and metformin (Glucovance®)
- Linagliptin and metformin (Jentadueto®)
- Pioglitazone and glimepiride (Duetact®)
- Pioglitazone and metformin (Actoplus Met®, Actoplus Met XR)
- Repaglinide and metformin (PrandiMet®)
- Rosiglitazone and glimepiride (Avandaryl®)
- Rosiglitazone and metformin (Avandamet®)
- Saxagliptin and metformin (Kombiglyze™ XR)
- Sitagliptin and metformin (Janumet®)
- Sitagliptin and metformin XR (Janumet® XR)
- Sitagliptin and simvastatin (Juvisync®), which is no longer available.