Actos Alternatives (Cont.)

 
Meglitinides
Meglitinides are similar to sulfonylureas (they work by forcing the pancreas to produce more insulin). However, they are short-acting and are less likely to cause dangerously low blood sugar. They are usually taken before every meal. Meglitinides include:
 
Thiazolidinediones (Glitazones)
These medications work mostly by helping the body to use its natural insulin better. In addition to Actos, there is one other glitazone currently available -- rosiglitazone (Avandia®).
 
Alpha Glucosidase Inhibitors
These medications prevent the breakdown of sugar and carbohydrates in the digestive tract, slowing their absorption. These medications are used to decrease blood sugar levels after meals. These medications include:
 
Dipeptidyl Peptidase Inhibitors
This is the newest class of oral diabetes medications. Currently, there is only one medication available in the group -- sitagliptin (Januvia®), although more medications in this group are currently under development. These medications increase incretin levels in the body. Incretin is a hormone that helps to control blood sugar in the body.
 
Combination Medications
There are a variety of combination medications available, including:
 

 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;